Beilstein J. Nanotechnol.2022,13, 114–126, doi:10.3762/bjnano.13.8
preclinical safety investigations delivered promising results. Bacterialsafety plays a decisive role during the production of HbMP. Therefore, the bioburden and endotoxin content of the starting materials (especially hemoglobin) and the final particle suspension are intensively tested. However, some bacteria
final particle suspensions. Therefore, we conclude that the HbMP fabrication procedure is safe in respect of bacterial contamination.
Keywords: bacterialsafety; EDTA; glutaraldehyde; hemoglobin; microparticles; Introduction
Artificial oxygen carriers used as red blood cell (RBC) substitutes have
animals are declared fit for human consumption after a post-mortem inspection. In the geographical area where the blood is collected, many critical viral pathogens do not occur [10]. Nevertheless, the blood is tested for viral contamination. In terms of bacterialsafety, the blood and the hemoglobin
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Figure 1:
Microscopic images of HbMP. (A, D) SEM images of dried and adherent particles after precipitation w...